Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Brain organoid reservoir computing for artificial intelligence
Brain-inspired computing hardware aims to emulate the structure and working principles of
the brain and could be used to address current limitations in artificial intelligence …
the brain and could be used to address current limitations in artificial intelligence …
Challenges and opportunities for the next generation of cardiovascular tissue engineering
Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
Human disease models in drug development
A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …
disease models owing to the notoriously high failure rates of the current drug development …
Emerging technologies in multi‐material bioprinting
Bioprinting, within the emerging field of biofabrication, aims at the fabrication of functional
biomimetic constructs. Different 3D bioprinting techniques have been adapted to bioprint cell …
biomimetic constructs. Different 3D bioprinting techniques have been adapted to bioprint cell …
Cell culture in microfluidic droplets
Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …
technologies, with the development of single-cell screening. However, the droplet format has …
Human organoids: New strategies and methods for analyzing human development and disease
NS Corsini, JA Knoblich - Cell, 2022 - cell.com
For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …
obtained primarily by experiments in animal models. While this has allowed researchers to …
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
Growth anisotropy of the extracellular matrix shapes a developing organ
Final organ size and shape result from volume expansion by growth and shape changes by
contractility. Complex morphologies can also arise from differences in growth rate between …
contractility. Complex morphologies can also arise from differences in growth rate between …