The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

The future of personalized medicine in space: from observations to countermeasures

E Pavez Loriè, S Baatout, A Choukér… - … in bioengineering and …, 2021 - frontiersin.org
The aim of personalized medicine is to detach from a “one-size fits all approach” and
improve patient health by individualization to achieve the best outcomes in disease …

Apollo lunar astronauts show higher cardiovascular disease mortality: possible deep space radiation effects on the vascular endothelium

MD Delp, JM Charvat, CL Limoli, RK Globus… - Scientific reports, 2016 - nature.com
As multiple spacefaring nations contemplate extended manned missions to Mars and the
Moon, health risks could be elevated as travel goes beyond the Earth's protective …

Growing tissues in real and simulated microgravity: new methods for tissue engineering

D Grimm, M Wehland, J Pietsch… - … Engineering Part B …, 2014 - liebertpub.com
Tissue engineering in simulated (s-) and real microgravity (r-μ g) is currently a topic in Space
medicine contributing to biomedical sciences and their applications on Earth. The principal …

The impact of microgravity and hypergravity on endothelial cells

JAM Maier, F Cialdai, M Monici… - BioMed research …, 2015 - Wiley Online Library
The endothelial cells (ECs), which line the inner surface of vessels, play a fundamental role
in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow …

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging

TJ Corydon, S Kopp, M Wehland, M Braun, A Schütte… - Scientific reports, 2016 - nature.com
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …

Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space

X Ma, J Pietsch, M Wehland, H Schulz… - The FASEB …, 2014 - Wiley Online Library
This study focuses on the effects of short‐term [22 s, parabolic flight campaign (PFC)] and
long‐term (10 d, Shenzhou 8 space mission) real microgravity on changes in cytokine …

The impact of simulated and real microgravity on bone cells and mesenchymal stem cells

C Ulbrich, M Wehland, J Pietsch… - BioMed research …, 2014 - Wiley Online Library
How microgravity affects the biology of human cells and the formation of 3D cell cultures in
real and simulated microgravity (r‐and s‐µg) is currently a hot topic in biomedicine. In r‐and …

Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity

C Buken, J Sahana, TJ Corydon, D Melnik, J Bauer… - Scientific Reports, 2019 - nature.com
The literature suggests morphological alterations and molecular biological changes within
the cellular milieu of human cells, exposed to microgravity (µ g), as many cell types …

Zebrafish bone and general physiology are differently affected by hormones or changes in gravity

J Aceto, R Nourizadeh-Lillabadi, R Maree… - PloS one, 2015 - journals.plos.org
Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic
and developmental studies. Our understanding of the physiological consequences of altered …