The fight against cancer by microgravity: the multicellular spheroid as a metastasis model
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
The future of personalized medicine in space: from observations to countermeasures
E Pavez Loriè, S Baatout, A Choukér… - … in bioengineering and …, 2021 - frontiersin.org
The aim of personalized medicine is to detach from a “one-size fits all approach” and
improve patient health by individualization to achieve the best outcomes in disease …
improve patient health by individualization to achieve the best outcomes in disease …
Apollo lunar astronauts show higher cardiovascular disease mortality: possible deep space radiation effects on the vascular endothelium
As multiple spacefaring nations contemplate extended manned missions to Mars and the
Moon, health risks could be elevated as travel goes beyond the Earth's protective …
Moon, health risks could be elevated as travel goes beyond the Earth's protective …
Growing tissues in real and simulated microgravity: new methods for tissue engineering
Tissue engineering in simulated (s-) and real microgravity (r-μ g) is currently a topic in Space
medicine contributing to biomedical sciences and their applications on Earth. The principal …
medicine contributing to biomedical sciences and their applications on Earth. The principal …
The impact of microgravity and hypergravity on endothelial cells
JAM Maier, F Cialdai, M Monici… - BioMed research …, 2015 - Wiley Online Library
The endothelial cells (ECs), which line the inner surface of vessels, play a fundamental role
in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow …
in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow …
Alterations of the cytoskeleton in human cells in space proved by life-cell imaging
TJ Corydon, S Kopp, M Wehland, M Braun, A Schütte… - Scientific reports, 2016 - nature.com
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space
This study focuses on the effects of short‐term [22 s, parabolic flight campaign (PFC)] and
long‐term (10 d, Shenzhou 8 space mission) real microgravity on changes in cytokine …
long‐term (10 d, Shenzhou 8 space mission) real microgravity on changes in cytokine …
The impact of simulated and real microgravity on bone cells and mesenchymal stem cells
C Ulbrich, M Wehland, J Pietsch… - BioMed research …, 2014 - Wiley Online Library
How microgravity affects the biology of human cells and the formation of 3D cell cultures in
real and simulated microgravity (r‐and s‐µg) is currently a hot topic in biomedicine. In r‐and …
real and simulated microgravity (r‐and s‐µg) is currently a hot topic in biomedicine. In r‐and …
Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity
The literature suggests morphological alterations and molecular biological changes within
the cellular milieu of human cells, exposed to microgravity (µ g), as many cell types …
the cellular milieu of human cells, exposed to microgravity (µ g), as many cell types …
Zebrafish bone and general physiology are differently affected by hormones or changes in gravity
J Aceto, R Nourizadeh-Lillabadi, R Maree… - PloS one, 2015 - journals.plos.org
Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic
and developmental studies. Our understanding of the physiological consequences of altered …
and developmental studies. Our understanding of the physiological consequences of altered …