The emergence of peptide–drug conjugates (PDCs) that utilize target-oriented peptide
moieties as carriers of cytotoxic payloads, interconnected with various cleavable …

Cancer is the uncontrolled division of abnormal cells in a specific organ. Globally, about one
in six deaths is due to cancer. Despite the plethora of research being undertaken worldwide …

High-risk neuroblastoma (NB) represents a major clinical challenge in pediatric oncology
due to relapse of metastatic, drug-resistant disease, and treatment-related toxicities. An …

miR-29a/b1 was reportedly involved in the regulation of the reproductive function in female
mice, but the underlying molecular mechanisms are not clear. In this study, female mice …

The development of peptide drugs has made tremendous progress in the past few decades
because of the advancements in modification chemistry and analytical technologies. The …

Peptide-drug conjugates (PDCs) are emerging therapeutic agents composed of peptides,
linkers, and payloads, which possess favorable targeting capability and can deliver enough …

The gonadotropin releasing hormone receptor (GnRH-R) is a G protein-coupled receptor
(GPCR) belonging to the rhodopsin family. GnRH-R antagonists suppress testosterone to …

Kidney disease is common in cancer patients, with almost 20% of all solid tumor patients
having an estimated glomerular filtration rate (GFR; eGFR)< 60 mL/min. Kidney function is …

FBS: borjú szérum albumin FSH: follikulus stimuláló hormon FZD6: frizzled class receptor 6
GAPDH: glicerinaldhehid-3-foszfát dehidrogenáz GHRH: növekedési hormon-releasing …

A programozott sejthalál, és ennek egyik fontos formája, az apoptózis a veszélyt jelentő
sejtek eltávolításának egyik fontos útvonala. 1 Az apoptózis elkerülése a rák kifejlődésének …