Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation,
migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

The brain is composed of many lipids with varied forms that serve not only as structural
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …

After they are born and differentiate, neurons break their previous symmetry, dramatically
change their shape, and establish two structurally and functionally distinct compartments …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

Myelin-associated inhibitors limit axonal regeneration in the injured brain and spinal cord. A
common target of many neurite outgrowth inhibitors is the Rho family of small GTPases …

The evolutionarily conserved execution phase of apoptosis is defined by characteristic
changes occurring during the final stages of death; specifically cell shrinkage, dynamic …

Regeneration in the CNS is blocked by many different growth inhibitory proteins. To foster
regeneration, we have investigated a strategy to block the neuronal response to growth …