Histone demethylation is a key post-translational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

Post‑translational modifications of histones by histone demethylases have an important role
in the regulation of gene transcription and are implicated in cancers. Recently, the family of …

Metformin has been used for the treatment of type II diabetes mellitus for decades due to its
safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying …

Lung cancer maintains a relatively small survival rate (~ 19%) over a 5-year period and up to
80–85% of all lung cancer diagnoses are Non-Small Cell Lung Cancer (NSCLC). To …

Background: Breast tumor inflammation is an immunological process that occurs mainly by
mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of …

Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to
treat cancer. These agents, usually combined with drugs, such as gemcitabine or …

Hepatocellular carcinoma (HCC) associated with viral or metabolic liver diseases is a
growing cancer that lacks effective therapy. AMPK is downregulated in the early stages of …

Sorafenib is a first-line chemotherapy drug for advanced hepatocellular carcinoma (HCC),
but the drug resistance appeared over time. Hypoxia and acidosis are common features of …

Sažetak Nesitnoćelijski karcinom pluća (NSCLC) sačinjava 80-85% svih dijagnostikovanih
formi karcinoma pluća. Konvencionalni terapijski modaliteti pokazuju malu uspešnost u …

Out of the all newly diagnosed lung cancers, non-small cell lung carcinoma (NSCLC)
comprises 80-85%. When treating advanced stages of the disease, conventional therapy …