Abstract Bisphenol A (BPA; 4, 4′-isopropylidenediphenol) is an endocrine disruptor that is
used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy …

Male reproductive health has deteriorated in many countries during the last few decades. In
the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and …

The proliferation and differentiation of a stem cell are regulated intrinsically by the stem cell
and extrinsically by the stem cell niche. Elucidation of regulatory mechanisms of …

Spermatogenesis occurs within the seminiferous tubules of mammals by a complex process
that is highly organized, extremely efficient and very productive. At the foundation of this …

Glial cell line-derived neurotrophic factor (GDNF) plays a crucial role in regulating the
proliferation of spermatogonial stem cells (SSC). The signaling pathways mediating the …

Culture and differentiation of male germ cells has been performed for various purposes in
the past. To date, none of the studies aimed at in vitro spermatogenesis has resulted in a …

Gene expression in higher eukaryotic cells orchestrates interactions between thousands of
RNA-binding proteins (RBPs) and tens of thousands of RNAs. The kinetics by which RBPs …

Establishing mammalian germ-cell lines capable of differentiation in vitro would greatly
facilitate the study of gametogenesis and the meiotic process that is so fundamental for …

Bisphenol A (BPA) is a plasticizer used widely in many industrial products and is now well
established as an endocrine-disrupting chemical (EDC). BPA readily leaches out from these …

Recent studies by Brinster and col-leagues reported in this issue of theProceedings (1, 2)
have shown that the in-jection of spermatogonial stem cells into the testes of sterile recipient …