Evaluation of testicular functions (production of sperm and androgens) is an important
aspect of preclinical safety assessment and testicular toxicity is comparatively far more …

STUDY QUESTION Which genes are confidently linked to human monogenic male
infertility? SUMMARY ANSWER Our systematic literature search and clinical validity …

Spermatogenesis is completely dependent on the pituitary hormone follicle-stimulating
hormone (FSH) and androgens locally produced in response to luteinising hormone (LH) …

The recent unraveling of structures of genes for the gonadotropin subunits and gonadotropin
receptors has provided reproductive endocrinologists with new tools to study normal and …

To study further the role of gonadotropins in reproductive functions, we generated mice with
LH receptor (LHR) knockout (LuRKO) by inactivating, through homologous recombination …

FSH was first identified in 1930 and is central to mammalian reproduction. It is indeed
intriguing that despite being researched upon for about 90 years, there is still so much more …

The aim of this review is to provide an integrative analysis of the role of FSH in the control of
testicular function in higher primates, including man. Attention is focused on the action of …

Azoospermia due to obstructive and non-obstructive mechanisms is a common
manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors …

This review describes the regulation of spermatogenesis taking into consideration the
hypothalamic–pituitary gonadal axis, the male reproductive organs and the endocrine and …

The testes produce the male gametes and the male sexual hormones (androgens). The term
spermatogenesis describes and includes all the processes involved in the production of …