This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

Abstract p53 is the most commonly mutated gene in human cancer. After activation by
cellular stresses such as DNA damage or oncogene activation, p53, a sequence-specific …

Proteins containing “cold shock” domains belong to the most evolutionarily conserved family
of nucleic acid-binding proteins known among bacteria, plants, and animals. One of these …

YB‐1 is a multifunctional protein involved in the regulation of transcription, translation,
mRNA splicing and probably DNA repair. It contains a conserved cold shock domain and it …

Gene expression can be regulated by nuclear factors at the transcriptional level. Many such
factors regulate MDR1 gene expression, but what are the sequence elements and …

The p53 tumor suppressor plays a major role in preventing tumor development by
transactivating genes to remove or repair potentially tumorigenic cells. Here we show that …

Introduction Genomic and transcriptomic alterations affecting key cellular processes such us
cell proliferation, differentiation and genomic stability are considered crucial for the …

Glioma stem cells (GSCs) are the important cause of tumorigenesis, recurrence, and chemo
(radio) resistance in glioma. Targeting GSCs helps improve the outcomes of glioma …

In previous studies we identified the transcription/translation factor Y‐box‐binding protein
(YB‐1) as a gene that is upregulated in primary melanoma and melanoma metastases when …