Worldwide research trends on medicinal plants

E Salmerón-Manzano, JA Garrido-Cardenas… - International journal of …, 2020 - mdpi.com
The use of medicinal plants has been done since ancient times and may even be
considered the origin of modern medicine. Compounds of plant origin have been and still …

Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy

CA Dehelean, I Marcovici, C Soica, M Mioc… - Molecules, 2021 - mdpi.com
Despite the recent advances in the field of chemically synthetized pharmaceutical agents,
nature remains the main supplier of bioactive molecules. The research of natural products is …

Implications of genetic and epigenetic alterations of CDKN2A (p16INK4a) in cancer

R Zhao, BY Choi, MH Lee, AM Bode, Z Dong - EBioMedicine, 2016 - thelancet.com
Aberrant gene silencing is highly associated with altered cell cycle regulation during
carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor gene, which …

[HTML][HTML] Broad targeting of angiogenesis for cancer prevention and therapy

Z Wang, C Dabrosin, X Yin, MM Fuster, A Arreola… - Seminars in cancer …, 2015 - Elsevier
Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

[HTML][HTML] Sulforaphane: A broccoli bioactive phytocompound with cancer preventive potential

AE Kaiser, M Baniasadi, D Giansiracusa… - Cancers, 2021 - mdpi.com
There is substantial and promising evidence on the health benefits of consuming broccoli
and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin …

Sp1 transcription factor: A long-standing target in cancer chemotherapy

C Vizcaíno, S Mansilla, J Portugal - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

Anticancer potential of garlic and its bioactive constituents: A systematic and comprehensive review

D De Greef, EM Barton, EN Sandberg… - Seminars in cancer …, 2021 - Elsevier
Vegetables of the Allium genus, such as garlic (Allium sativum L.), onions, shallots, leaks,
and chives, have been used for many years for food consumption and for medicinal …

Targeting the JAK/STAT signaling pathway using phytocompounds for cancer prevention and therapy

S Bose, S Banerjee, A Mondal, U Chakraborty… - Cells, 2020 - mdpi.com
Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway …

Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability

H Wang, T Oo Khor, L Shu, ZY Su… - Anti-Cancer Agents …, 2012 - ingentaconnect.com
Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …

The risk factors of prostate cancer and its prevention: a literature review

NR Perdana, CA Mochtar, R Umbas… - Acta medica …, 2017 - actamedindones.org
This is a literature review study. Data was obtained from several literature reviews and
journal resources that have correlation with the risk factors involved in PCa including age …