Tumor cells have developed various mechanisms in defense against applied treatment,
which prevent their total elimination from an organism. One of the underestimated …

Exosomes are mobile extracellular vesicles with a diameter 40 to 150 nm. They play a
critical role in several processes such as the development of cancers, intercellular signaling …

Lentiviral vectors are efficient vehicles for stable gene transfer in both dividing and non-
dividing cells. This feature among others makes lentiviral vectors a powerful tool in …

Polyether ionophore salinomycin (SAL) and its semi-synthetic derivatives are recognized as
very promising anticancer drug candidates due to their activity against various types of …

Background: Despite the high prevalence of depression, the mechanism of the origin of this
disease as well as the causes of resistance to therapy in some patients are still not fully …

Background: Breast cancer is the leading cause of cancer death among women and the
second in humans worldwide. Many published studies have suggested an association …

Introduction The dopaminergic system plays a crucial role in the development of alcohol
dependence. Regulation of the extracellular dopamine concentration is driven by dopamine …

Background Breast cancer is the most common cause of cancer death among women.
Several studies have investigated the relationship between the C3435T polymorphism of …

Telomere shortening is associated with cancer development, primarily through the induction
of genomic instability. The majority of studies have indicated that individuals with shorter …

Abstract The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1
(MDR1), has demonstrated its role in decreasing the P-gp activity level which is related to …