With the accomplishment of human genome sequencing, the number of sequence-known
proteins has increased explosively. In contrast, the pace is much slower in determining their …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent
to develop automated methods for analyzing the relationship between the sequences and …

Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …

Prediction of protein subcellular localization is a challenging problem, particularly when the
system concerned contains both singleplex and multiplex proteins. In this paper, by …

In the last two decades or so, although many computational methods were developed for
predicting the subcellular locations of proteins according to their sequence information, it is …

Nuclear receptors (NRs) are one of the most abundant classes of transcriptional regulators
in animals. They regulate diverse functions, such as homeostasis, reproduction …

Nuclear receptors (NRs) form a family of ligand-activated transcription factors that regulate a
wide variety of biological processes, such as homeostasis, reproduction, development, and …

During the past, there was a massive growth of knowledge of unknown proteins with the
advancement of high throughput microarray technologies. Protein function prediction is the …

Background Because a priori knowledge about function of G protein-coupled receptors
(GPCRs) can provide useful information to pharmaceutical research, the determination of …