Fatty acid–binding proteins (FABPs) are small lipid-binding proteins abundantly expressed
in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have …

BACKGROUND The precise movement of proteins and vesicles is an essential ability for all
eukaryotic cells. Nowhere is this more evident than during the remarkable transformation …

Mammalian spermiogenesis is a remarkable cellular transformation, during which round
spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that …

Male idiopathic infertility accounts for 15–25% of reproductive failure. One of the factors that
has been linked to this condition is oxidative stress (OS), defined as the imbalance between …

The hypothalamus–pituitary–testis axis controls the production of spermatozoa, and the
kisspeptin system, comprising Kiss1 and Kiss1 receptor (Kiss1R), is the main central …

The acrosome located within the mammalian sperm head is essential for successful
fertilization, as it enables the sperm to penetrate the extracellular layers of the oocyte and …

The postacrosomal sheath (PAS) of the perinuclear theca (PT) is the first compartment of the
sperm head to solubilize into the ooplasm upon sperm-oocyte fusion, implicating its …

The perinuclear theca (PT) of the eutherian sperm head is a cytoskeletal-like structure that
houses proteins involved in important cellular processes during spermiogenesis and …

Structural and regulatory requirements of mammalian spermatozoa in both development
and function make them extremely unique cells. Looking at the complexity of spermatozoon …

Nuclear vacuoles are specific structures present on the head of the human sperm of fertile
and non-fertile men. Human sperm head vacuoles have been previously studied using …