Apolipoprotein E (apoE) is a major apolipoprotein involved in lipoprotein metabolism. It is a
polymorphic protein and different isoforms are associated with variations in lipid and …

Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …

Abstract Purpose of Review Hypertriglyceridemia is a common dyslipidemia associated with
an increased risk of cardiovascular disease and pancreatitis. Severe hypertriglyceridemia …

Apolipoprotein (apo) E mutants are associated with type III hyperlipoproteinemia
characterized by high cholesterol and triglycerides levels. Autosomal dominant …

Abstract Context: The p. Leu167del mutation in the APOE gene has been associated with
hyperlipidemia. Objectives: Our objective was to determine the frequency of p. Leu167del …

Background Autosomal dominant hypercholesterolemia (ADH) is caused by mutations in the
low density lipoprotein receptor (LDLR), its ligand apoB (APOB) or proprotein convertase …

Among different types of dyslipidemia, familial combined hyperlipidemia (FCHL) is the most
common genetic disorder, which is characterized by at least two different forms of lipid …

Background and aims Lipoprotein (a)[Lp (a)] concentration in heterozygous familial
hypercholesterolemia (heFH) is not well established. Whether the genetic defect responsible …

Abstract Hyperlipoproteinemia type 3 (HLP3) is caused by impaired removal of triglyceride-
rich lipoproteins (TGRL) leading to accumulation of TGRL remnants with abnormal …

Background Familial dysbetalipoproteinemia (FDBL) is a monogenic disease due to variants
in APOE with a highly variable phenotype. Current diagnostic lipid-based methods have …