Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Phagocytic activity of glial cells is essential for proper nervous system sculpting,
maintenance of circuitry, and long-term brain health. Glial engulfment of apoptotic cells and …

Neuronal circuit assembly requires the fine balance between synapse formation and
elimination. Microglia, through the elimination of supernumerary synapses, have an …

Mammalian photoreceptor outer segment renewal is a highly coordinated process that
hinges on timed cell signaling between photoreceptor neurons and the adjacent retinal …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that manifests as
cognitive deficits and memory decline, especially in old age. Several biomarkers have been …

Retinitis Pigmentosa (RP) is a group of inherited retinal diseases characterized by
progressive loss of rod followed by cone photoreceptors. An especially early onset form of …

Clearance phagocytosis is a documented function of Müller glia in the retina. However, the
molecular mechanisms of Müller glia phagocytosis remain largely undefined. Here, we show …

Outer segment phagocytosis (OSP) is a highly‐regulated, biological process wherein
photoreceptor outer segment (OS) tips are cyclically phagocytosed by the adjacent retinal …

Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2)
gene that codes for pigment epithelium-derived factor receptor (PEDF-R)(also known as …

Ischemia-induced retinopathy is a hallmark finding of common visual disorders including
diabetic retinopathy (DR) and central retinal artery and vein occlusions. Treatments for …