[HTML][HTML] Capsaicin, the vanilloid receptor TRPV1 agonist in neuroprotection: mechanisms involved and significance

OME Abdel-Salam, G Mózsik - Neurochemical Research, 2023 - Springer
Hot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family
Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8 …

[HTML][HTML] Beneficial effects of capsaicin in disorders of the central nervous system

M Pasierski, B Szulczyk - Molecules, 2022 - mdpi.com
Capsaicin is a natural compound found in chili peppers and is used in the diet of many
countries. The important mechanism of action of capsaicin is its influence on TRPV1 …

Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation‐induced synaptic damage and cognitive dysfunction via autophagy enhancement

T Zhang, Y Tian, X Zheng, R Li, L Hu… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims The autophagy‐lysosomal pathway is important for maintaining cellular proteostasis,
while dysfunction of this pathway has been suggested to drive the aberrant intraneuronal …

[HTML][HTML] A systematic review of the effects of capsaicin on Alzheimer's disease

D Inyang, T Saumtally, CN Nnadi, S Devi… - International Journal of …, 2023 - mdpi.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterised by
cognitive impairment, and amyloid-β plaques and neurofibrillary tau tangles at …

TRPV1 Modulator Ameliorates Alzheimer‐Like Amyloid‐β Neuropathology via Akt/Gsk3β‐Mediated Nrf2 Activation in the Neuro‐2a/APP Cell Model

X Wang, Y Bian, CTT Wong, JH Lu… - Oxidative Medicine and …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder for
which there is no effective therapeutic strategy. PcActx peptide from the transcriptome of …

Inhibition potential against acetylcholinesterase of commercial and extracts of capsaicin and dihydrocapsaicin by in vitro and in silico studies

P Mansalai, N Intanon, A Payaka… - Process …, 2024 - Elsevier
The present research investigates the amount of capsaicin and dihydrocapsaicin in three
parts of chili extracts (pericarp, seeds, and placenta). Moreover, inhibition potential of …

Roles of receptor‐interacting protein kinase 1 in SH‐SY5Y cells with beta amyloid‐induced neurotoxicity

HH Chan, CO Leong, CL Lim… - Journal of Cellular and …, 2022 - Wiley Online Library
Abstract Alzheimer's disease (AD), the major cause of dementia, affects the elderly
population worldwide. Previous studies have shown that depletion of receptor‐interacting …

Pharmacological evaluation of green chilli in Alzheimer's disease

P Perumal, DYH Chong - Pharmacognosy Research, 2022 - phcogres.com
Background: Green chilli pepper (Capsicum annum L. car frutescens) is popular as a spice
used in many cuisines across the world. Capsaicin, as the pharmacologically active …

Therapeutic Effects of Capsaicin on Central Nervous Disorders with Special Emphasis on Parkinson's and Alzheimer's Diseases

D Dutta, D Tripathi, P Asthana, K Rana, N Jain… - … : From Natural Sources …, 2024 - Springer
The two major neurodegenerative diseases, viz., Parkinson's disease (PD) and Alzheimer's
disease (AD), are incurable so far. These diseases are even difficult to manage as their …

[HTML][HTML] Indonesian native medicinal plants of mechanisms and potential compounds as anti-Alzheimer's

DJ MAYSHA, V EARLINE… - Prosiding Seminar …, 2023 - smujo.id
Maysha DJ, Earline V, Hastilestari BR. 2023. Indonesian native medicinal plants of
mechanisms and potential compounds as anti-Alzheimer's. Pros Sem Nas Masy Biodiv …