Omics of blood pressure and hypertension

DK Arnett, SA Claas - Circulation Research, 2018 - Am Heart Assoc
Essential hypertension is a common, complex disorder affecting≤ 1 billion adults globally.
Blood pressure is a highly heritable trait, with≤ 50% of the variation between individuals …

Metabolomics profiling in hypertension and blood pressure regulation: a review

JO Onuh, M Aliani - Clinical hypertension, 2020 - Springer
Hypertension is a chronic health condition in which blood pressure is usually elevated
beyond normal levels. It can progress with serious complications if left undetected and …

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes

C Menni, J Zhu, CI Le Roy, O Mompeo, K Young… - Gut …, 2020 - Taylor & Francis
ABSTRACT Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity,
although the cause is unclear. Metabolites generated by gut microbes also appear to be …

The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial …

AE Schutte, PN Gona, C Delles, AS Uys… - European journal of …, 2019 - academic.oup.com
Background Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of
hypertension remains on an increase. Although this might be attributed to poor healthcare …

Identification of essential hypertension biomarkers in human urine by non-targeted metabolomics based on UPLC-Q-TOF/MS

H Zhao, Y Liu, Z Li, Y Song, X Cai, Y Liu, T Zhang… - Clinica chimica acta, 2018 - Elsevier
Background In recent years, using metabolomics technology to study hypertension has
made some progress. However, in actual clinical studies, there are few studies on …

Study on urine metabolic profiling and pathogenesis of hyperlipidemia

L Yang, Z Li, Y Song, Y Liu, H Zhao, Y Liu, T Zhang… - Clinica chimica acta, 2019 - Elsevier
Background As a recognized risk factor for cardiovascular disease (CVD), hyperlipidemia
(HLP) has developed into a high incidence disease that seriously threatens human health …

The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and …

AM El-Baz, A Shata, HM Hassan… - International …, 2021 - Elsevier
Male reproductive dysfunction is one of the overlooked findings of diabetes mellitus (DM)
that deserves greater scientific attention. This study is designed to explore the therapeutic …

Identification of biomarkers for essential hypertension based on metabolomics

Y Deng, C Huang, J Su, CW Pan, C Ke - Nutrition, Metabolism and …, 2021 - Elsevier
Aim Essential hypertension (EH) is one of the most important public health problems
worldwide. However, the pathogenesis of EH is unclear and early diagnostic methods are …

An untargeted metabolomics study of blood pressure: findings from the Bogalusa Heart Study

WJ He, C Li, X Mi, M Shi, X Gu, LA Bazzano… - Journal of …, 2020 - journals.lww.com
Objective: To identify novel and confirm previously reported metabolites associated with
SBP, DBP, and hypertension in a biracial sample of Bogalusa Heart Study (BHS) …

Ultrahigh resolution MS1/MS2-based reconstruction of metabolic networks in mammalian cells reveals changes for selenite and arsenite action

TWM Fan, Q Sun, RM Higashi - Journal of Biological Chemistry, 2022 - ASBMB
Metabolic networks are complex, intersecting, and composed of numerous enzyme-
catalyzed biochemical reactions that transfer various molecular moieties among metabolites …