Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

Neurofibromatosis type 1 is a relatively common genetic disease, with a prevalence ranging
between 1/3000 and 1/6000 people worldwide. The disease affects multiple systems with …

Neurofibromatosis 1 (NF1) is a common neurocutaneous condition with an autosomal
dominant pattern of inheritance. The complications are diverse and disease expression …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Optic pathway glioma (OPG), seen in 15% to 20% of individuals with neurofibromatosis type
1 (NF1), account for significant morbidity in young children with NF1. Overwhelmingly a …

Neurofibromatosis type 1 (NF1) is one of the most common brain tumor predisposition
syndromes, in which affected children are prone to the development of low-grade gliomas …

Summary Historically, neurofibromatosis 1 (NF1) has been inextricably linked with
neurofibromatosis 2 (NF2). Both are inherited autosomal-dominant neurocutaneous …

Abstract Neurofibromatosis 1 (NF1) is an inherited neurocutaneous disease that has a major
impact on the nervous system, eye, skin, and bone. Individuals with NF1 have a …

Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1
(NF1); up to half become symptomatic. There is little information regarding ophthalmologic …

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome
that affects children and adults. Individuals with NF1 are at high risk for central nervous …