Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

From reviews to the first edtion:" Bornscheuer and Kazlauskas have set out, and succeeded,
in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and …

This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products
play important roles in biotransformation of ester-or amide-type prodrugs. They are members …

Enzymes are essential for the activation of many prodrugs. In this review, the most important
enzymes (eg, paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) …

The degree of stability of antibody–drug linkers in systemic circulation, and the rate of their
intracellular processing within target cancer cells are among the key factors determining the …

Human carboxylesterase 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE,
HU3) are a serine esterase involved in both drug metabolism and activation. Although both …

Carboxylesterases hydrolyze numerous endogenous and exogenous ester-containing
compounds. They play a role in the detoxification of many agrochemicals including …