A series of new hydrazone derivatives: Synthesis, molecular docking and anticholinesterase activity studies
Background: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is …
Development of a novel class of pyridazinone derivatives as selective MAO-B inhibitors
Sixteen compounds (TR1–TR16) were synthesized and evaluated for their inhibitory
activities against monoamine oxidase A and B (MAOs). Most of the derivatives showed …
activities against monoamine oxidase A and B (MAOs). Most of the derivatives showed …
Synthesis and in vitro study of new coumarin derivatives linked to nicotinonitrile moieties as potential acetylcholinesterase inhibitors
Abstract The appropriate pyridine‐2 (1 H)‐thiones were reacted with an equivalent amount
of 5‐(chloromethyl)‐2‐hydroxybenzaldehyde in ethanol in the presence of potassium …
of 5‐(chloromethyl)‐2‐hydroxybenzaldehyde in ethanol in the presence of potassium …
Synthesis of (p‐tolyl)‐3(2H)pyridazinone Derivatives as Novel Acetylcholinesterase Inhibitors
In this study, a series of N‐substituted‐(p‐tolyl) pyridazin‐3 (2H)‐one derivatives were
synthesized and evaluated for their AChE inhibitory activity. The chemical structures of novel …
synthesized and evaluated for their AChE inhibitory activity. The chemical structures of novel …
A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies
Background The pyridazinone nucleus has been incorporated into a wide variety of
therapeutically interesting molecules to transform them into better drugs …
therapeutically interesting molecules to transform them into better drugs …
Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker
Novel twenty-three 3 (2 H)-pyridazinone derivatives were designed and synthesized based
on the chemical requirements related to the anti-proliferative effects previously …
on the chemical requirements related to the anti-proliferative effects previously …
Novel thiazole‐piperazine derivatives as potential cholinesterase inhibitors
Ş Demirayak, Z Şahin, M Ertaş… - Journal of …, 2019 - Wiley Online Library
Dementia is a cognitive disorder mostly associated with Alzheimer's disease (AD) in addition
to being seen in many other diseases of the central nervous system (CNS). The limited …
to being seen in many other diseases of the central nervous system (CNS). The limited …
Design, synthesis, and bioevaluation of novel oxoindolin-2-one derivatives incorporating 1-benzyl-1H-1, 2, 3-triazole
In our search for novel bioactive molecules, three series of indolin-2-one derivatives
incorporating 1-benzyl-1H-1, 2, 3-triazole moiety were synthesized. The compounds were …
incorporating 1-benzyl-1H-1, 2, 3-triazole moiety were synthesized. The compounds were …
Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors
Background Since brain neurotransmitter levels are associated with the pathology of various
neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) …
neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) …
[PDF][PDF] Role of pyridazine analogs as acetylcholinesterase inhibitor: An approach for management of alzheimer's disease
S Alghamdi, M Asif - Eurasian Chem. Commun, 2021 - academia.edu
Alzheimer's disease(AD) is a neurodegenerative disorder, differentiated by the failure of
cognitive capacity and rigorous behavior deformities, which eventually lead to degradation …
cognitive capacity and rigorous behavior deformities, which eventually lead to degradation …