Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

The selective modification of nitrogen heteroaromatics enables the development of new
chemical tools and accelerates drug discovery. While methods that focus on expanding or …

The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

A practical method for the synthesis of 15N-labeled azines with a high degree of isotopic
enrichment is described. Activation of azine heterocycles with an electron-deficient arene …

Methods to incorporate stable radioisotopes are integral to pharmaceutical and
agrochemical development. However, despite the prevalence of pyridines in candidate …

Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that
ordinarily impractical measurements become possible. The potential to revolutionize …

Signal amplification by reversible exchange (SABRE) turns typically weak magnetic
resonance responses into strong signals making previously impractical measurements …

Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR
hyperpolarization method that uses cheap and readily available para-hydrogen as a …

Direct NMR hyperpolarization of naturally abundant 15N sites in metronidazole is
demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange in …