Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …

Evidence from observational studies and randomized trials suggests that prediabetes and
type 2 diabetes mellitus (T2DM) can develop in genetically susceptible individuals in …

A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …

Evidence is accumulating that the gut microbiome is involved in the aetiology of obesity and
obesity-related complications such as nonalcoholic fatty liver disease (NAFLD), insulin …

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Simple Summary Skeletal muscle mass is an important economic trait, and muscle
development and growth is a crucial factor to supply enough meat for human consumption …

Insulin resistance results when peripheral tissues, including adipose, skeletal muscle, and
liver, do not respond appropriately to insulin, causing the ineffective uptake of glucose. This …