A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Advances in 3D bioprinting of tissues/organs for regenerative medicine and in-vitro models

P Jain, H Kathuria, N Dubey - Biomaterials, 2022 - Elsevier
Tissue/organ shortage is a major medical challenge due to donor scarcity and patient
immune rejections. Furthermore, it is difficult to predict or mimic the human disease condition …

Decellularized extracellular matrix-based bioinks for engineering tissue-and organ-specific microenvironments

BS Kim, S Das, J Jang, DW Cho - Chemical reviews, 2020 - ACS Publications
Biomaterials-based biofabrication methods have gained much attention in recent years.
Among them, 3D cell printing is a pioneering technology to facilitate the recapitulation of …

Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems

SB Campbell, Q Wu, J Yazbeck, C Liu… - ACS biomaterials …, 2020 - ACS Publications
Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …

Chitosan-based inks for 3D printing and bioprinting

M Taghizadeh, A Taghizadeh, MK Yazdi, P Zarrintaj… - Green …, 2022 - pubs.rsc.org
The advent of 3D-printing/additive manufacturing in biomedical engineering field has
introduced great potential for the preparation of 3D structures that can mimic native tissues …

Print me an organ! Why we are not there yet

WL Ng, CK Chua, YF Shen - Progress in Polymer Science, 2019 - Elsevier
Bioprinting offers a highly-automated and advanced manufacturing platform that facilitates
the deposition of bio-inks (living cells, biomaterials and growth factors) in a scalable and …

Application of 3D bioprinting in the prevention and the therapy for human diseases

HG Yi, H Kim, J Kwon, YJ Choi, J Jang… - Signal Transduction and …, 2021 - nature.com
Rapid development of vaccines and therapeutics is necessary to tackle the emergence of
new pathogens and infectious diseases. To speed up the drug discovery process, the …

Designing decellularized extracellular matrix‐based bioinks for 3D bioprinting

A Abaci, M Guvendiren - Advanced healthcare materials, 2020 - Wiley Online Library
Abstract 3D bioprinting is an emerging technology to fabricate tissues and organs by
precisely positioning cells into 3D structures using printable cell‐laden formulations known …

3D Bioprinting of Vascularized Tissues for in vitro and in vivo Applications

EP Chen, Z Toksoy, BA Davis… - Frontiers in Bioengineering …, 2021 - frontiersin.org
With a limited supply of organ donors and available organs for transplantation, the aim of
tissue engineering with three-dimensional (3D) bioprinting technology is to construct fully …

Breakthroughs and applications of organ-on-a-chip technology

MC Koyilot, P Natarajan, CR Hunt, S Sivarajkumar… - Cells, 2022 - mdpi.com
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …