Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly
due to a lack of genotype calling and quality-control procedures. Developing an at-scale …

Environmental adaptation, predisposition to common diseases, and, potentially, speciation
may all be linked through the adaptive potential of mitochondrial DNA (mtDNA) alterations of …

Like any organ, the brain is susceptible to the march of time and a reduction in mitochondrial
biogenesis is a hallmark of the aging process. In the largest investigation of mitochondrial …

Leber's hereditary optic neuropathy is a maternally inherited blinding disease caused as a
result of homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. It is …

Leber hereditary optic neuropathy (LHON) is one of the most common inherited optic
neuropathies causing bilateral central vision loss. The disorder results from point mutations …

Understanding the factors that contribute to exercise response variation is the first step in
achieving the goal of developing personalized exercise prescriptions. This review discusses …

In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting
mitochondrial respiratory complex I. This initiated the long‐standing hypothesis that …