Immunosuppression regimens used in solid organ transplant have evolved significantly over
the past 70 years in the United States. Early immunosuppression and targets for allograft …

Lung transplantation can be a life-saving procedure for those with end-stage lung diseases.
Unfortunately, long term graft and patient survival are limited by both acute and chronic …

Objective To compare the efficacy of tacrolimus (TAC) and mycophenolate mofetil (MMF) for
the initial therapy of lupus nephritis (LN). Study design This is an open randomised …

Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection.
Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining …

Since the first heart transplantation (HT) in 1967, survival has steadily improved. Issues
related to over-and under-immunosuppression are, however, still common following HT …

The calcineurin inhibitors (CNIs) belong to a group of immunosuppressive agents that block
T-cell activation through the suppression of the calcium/calcimodulin-dependent …

Over the past decades, there has been an encouraging increase in survival after solid organ
transplantation. However, with longer life spans, more transplant recipients are at risk of …

Background Lung transplantation is a well‐accepted treatment for people with most end‐
stage lung diseases. Although both tacrolimus and cyclosporin are used as primary …

Background and Aims Several meta-analyses comparing ciclosporin with tacrolimus have
been conducted since the 1994 publication of the tacrolimus registration trials, but most …

Organ transplant can be a lifesaving treatment option for patients with end-stage organ
failure. Stem cell transplant is a treatment option for those with blood cancer, bone marrow …