Background Azathioprine and mercaptopurine have a pivotal role in the treatment of
inflammatory bowel disease (IBD). However, because of their complex metabolism and …

Systemic administration of corticosteroid (CS) remains the standard gold treatment for
pemphigus. However, because of several long-term adverse effects, steroid-sparing agents …

Oxidative stress plays an important role in IBD because chronic intestinal inflammation is
associated with the overproduction of reactive oxygen species (ROS) leading to oxidative …

Abstract Background The Mothers and Children's Environmental Health study (MOCEH) is a
multi-centric prospective birth cohort study investigating effects of various environmental …

Toxicity studies, among them hepatotoxicity, are key throughout preclinical stages of drug
development to minimise undesired toxic effects that might eventually appear in the course …

We aimed to evaluate the effects of Bisphenol-A (BPA) exposure on fetal/child growth from
the fetal period to 72 months after birth. The MOCEH study is a prospective birth cohort study …

Azathioprine and 6-mercaptopurine remain pivotal therapies for the maintenance of disease
remission in patients with Crohn's disease and ulcerative colitis. While thiopurine S …

Abstract Exactly 70 years ago [1951] mercaptopurine was discovered by Gertrude Elion as a
novel treatment option for acute leukaemia. A total of three thiopurines (also thioguanine …

Introduction: Inflammatory bowel disease is a chronic inflammation of the gut whose
pathogenesis is still unclear. Although no curative therapy is currently available, a number of …

Inflammatory bowel disease (IBD) involves a variety of conditions, particularly Crohn's
disease (CD) and ulcerative colitis (UC). IBD is characterized by chronic inflammatory …