Abstract The Aryl Hydrocarbon Receptor (AHR) is a ligand-dependent transcription factor
able to control complex transcriptional processes in several cell types, which has been …

The topic of uremic toxicity has received broad attention from the nephrological community
over the past few decades. An aspect that is much less often considered is the possibility …

Background Despite the great success, the therapeutic benefits of immune checkpoint
inhibitors (ICIs) in cancer immunotherapy are limited by either various resistance …

The microbiome is a predictor of clinical outcome in patients receiving allogeneic
hematopoietic stem cell transplantation (allo-SCT). Microbiota-derived metabolites can …

Polysaccharides are known to confer protection against glycolipid metabolism disorders
(GMD) by regulating intestinal flora. In this study, a heterogeneous acidic …

Uremic metabolites, molecules either produced by the host or from the microbiota population
existing in the gastrointestinal tract that gets excreted by the kidneys into urine, have …

Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a
progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier …

Background and purpose Cisplatin-induced nephrotoxicity manifests as acute kidney injury
(AKI) in approximately one third of patients receiving cisplatin therapy. Current measures of …

Tryptophan (Trp) is an essential amino acid which is unable to be synthesized in the body.
Main sources of Trp are uptake of foods such as oats and bananas. In this review, we …

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that poses
health challenges worldwide and is expected to continue to rise dramatically. NAFLD is …