Restless legs syndrome

M Manconi, D Garcia-Borreguero… - Nature reviews Disease …, 2021 - nature.com
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

Comorbidities, treatment, and pathophysiology in restless legs syndrome

C Trenkwalder, R Allen, B Högl, S Clemens… - The Lancet …, 2018 - thelancet.com
Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological
condition whose manifestation is affected by complex environmental and genetic …

[HTML][HTML] Restless legs syndrome: contemporary diagnosis and treatment

TR Gossard, LM Trotti, A Videnovic, EK St Louis - Neurotherapeutics, 2021 - Elsevier
Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs
while at rest, relief upon movement or getting up to walk, and worsened symptom severity at …

The restless legs syndrome

C Trenkwalder, W Paulus, AS Walters - The lancet neurology, 2005 - thelancet.com
The restless legs syndrome is a common disorder that encompasses an idiopathic form of
genetic or unknown origin and symptomatic forms associated with many causes …

Restless leg syndrome/Willis-Ekbom disease pathophysiology

RP Allen - Sleep medicine clinics, 2015 - sleep.theclinics.com
Three major clinical features of restless leg syndrome/Willis-Ekbom disease (RLS/WED)
unique for common neurologic disorders enabled somewhat surprising pathophysiologic …

Iron and restless legs syndrome: treatment, genetics and pathophysiology

JR Connor, SM Patton, K Oexle, RP Allen - Sleep medicine, 2017 - Elsevier
In this article, we review the original findings from MRI and autopsy studies that
demonstrated brain iron status is insufficient in individuals with restless legs syndrome …

Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment

R Gupta, M Dhyani, T Kendzerska… - Acta Neurologica …, 2016 - Wiley Online Library
Restless legs syndrome (RLS) is a common sleep disorder that may be associated with
pregnancy. Studies have found that the prevalence of RLS among pregnant women ranged …

[HTML][HTML] Restless legs syndrome across the lifespan: symptoms, pathophysiology, management and daily life impact of the different patterns of disease presentation

G Didato, R Di Giacomo, GJ Rosa, A Dominese… - International Journal of …, 2020 - mdpi.com
Restless legs syndrome is a common but still underdiagnosed neurologic disorder,
characterized by peculiar symptoms typically occurring in the evening and at night, and …

[HTML][HTML] Restless legs syndrome: current concepts about disease pathophysiology

BB Koo, K Bagai, AS Walters - Tremor and Other Hyperkinetic …, 2016 - ncbi.nlm.nih.gov
Background In the past few decades, much has been learned about the pathophysiology of
restless legs syndrome (RLS). Investigators have studied neuropathology, imaging …

Incident cardiovascular events and death in individuals with restless legs syndrome or periodic limb movements in sleep: a systematic review

T Kendzerska, M Kamra, BJ Murray, MI Boulos - Sleep, 2017 - academic.oup.com
Abstract Study Objectives: To systematically review the current evidence examining restless
legs syndrome (RLS) and periodic limb movements in sleep (PLMS) as prognostic factors for …