The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
[HTML][HTML] The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Abstract The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Consortium is a collaborative network of researchers working together on a range of large …
Consortium is a collaborative network of researchers working together on a range of large …
[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
[HTML][HTML] Predicting Alzheimer's disease progression using multi-modal deep learning approach
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by a decline
in cognitive functions with no validated disease modifying treatment. It is critical for timely …
in cognitive functions with no validated disease modifying treatment. It is critical for timely …
Effective feature learning and fusion of multimodality data using stage‐wise deep neural network for dementia diagnosis
In this article, the authors aim to maximally utilize multimodality neuroimaging and genetic
data for identifying Alzheimer's disease (AD) and its prodromal status, Mild Cognitive …
data for identifying Alzheimer's disease (AD) and its prodromal status, Mild Cognitive …
[HTML][HTML] Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease
Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of
Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels …
Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels …
Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults
SL Risacher, BC McDonald, EF Tallman… - JAMA …, 2016 - jamanetwork.com
Importance The use of anticholinergic (AC) medication is linked to cognitive impairment and
an increased risk of dementia. To our knowledge, this is the first study to investigate the …
an increased risk of dementia. To our knowledge, this is the first study to investigate the …
Latent representation learning for Alzheimer's disease diagnosis with incomplete multi-modality neuroimaging and genetic data
The fusion of complementary information contained in multi-modality data [eg, magnetic
resonance imaging (MRI), positron emission tomography (PET), and genetic data] has …
resonance imaging (MRI), positron emission tomography (PET), and genetic data] has …
Identification of common variants associated with human hippocampal and intracranial volumes
Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …
[HTML][HTML] Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities, and plans
Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …