The encoded biosynthesis of proteins provides the ultimate paradigm for high-fidelity
synthesis of long polymers of defined sequence and composition, but it is limited to …

Brown algae, as the main source of alginate, are a type of marine biomass with a very high
output. Alginate, a polysaccharide composed of β-D-mannuronic acid (M) and α-L-guluronic …

Decelerating global warming is one of the predominant challenges of our time and will
require conversion of CO 2 to usable products and commodity chemicals. Of particular …

Highlights•Predictability and robustness are major challenges for synthetic
biology.•Engineering bacteria requires putting synthetic constructs into growing host …

The increasing demands placed on natural resources for fuel and food production require
that we explore the use of efficient, sustainable feedstocks such as brown macroalgae. The …

It is generally believed that exchange of secondary metabolite biosynthetic gene clusters
(BGCs) among closely related bacteria is an important driver of BGC evolution and …

Methods for importing heterologous genes into genetically tractable hosts are among the
most desired tools of synthetic biology. Easy plug-and-play construction methods to rapidly …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Brown macroalgae have attracted great attention as an alternative feedstock for biorefining.
Although direct conversion of ethanol from alginates (major components of brown …

Exogenous pathway optimization and chassis engineering are two crucial methods for
heterologous pathway expression. The two methods are normally carried out step-wise and …