Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …

DNA damage repair deficiency leads to the increased risk of genome instability and
oncogenic transformation. In the meanwhile, this deficiency could be exploited for cancer …

The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of
breast cancer tumors. However, the underlying mechanism is not fully understood. Here …

Abstract Background Although both circular RNAs (circRNAs) and autophagy are associated
with the function of breast cancer (BC), whether circRNAs regulate BC progression via …

Cancer therapy through anticancer drugs and radiotherapy is associated with several side
effects as well as tumor resistance to therapy. The genotoxic effects of chemotherapy and …

Genomic instability is a hallmark of cancer, and has a central role in the initiation and
development of breast cancer,. The success of poly-ADP ribose polymerase inhibitors in the …

Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …

Breast cancer remains the most frequently diagnosed malignancy among women
worldwide. Although effective, numerous treatment strategies have been developed, which …

Purpose Breast cancer (BC), with varying histopathology, biology and response to systemic
treatment, is the second leading cause of cancer-related mortality. Previous studies have …

Breast cancer (BC) is the first worldwide most frequent cancer in both sexes and the most
commonly diagnosed in females. Although BC mortality has been thoroughly declining over …