The integrated brain network that controls respiration
F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …
Itch: from mechanism to (novel) therapeutic approaches
G Yosipovitch, JD Rosen, T Hashimoto - Journal of allergy and clinical …, 2018 - Elsevier
Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …
diseases, as well as in those with systemic and neuropathic conditions. In patients with …
Peripheral and central mechanisms of itch
X Dong, X Dong - Neuron, 2018 - cell.com
Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …
Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception
Y Jang, M Kim, SW Hwang - Journal of Neuroinflammation, 2020 - Springer
Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …
TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization
O Gouin, K L'herondelle, N Lebonvallet… - Protein & …, 2017 - academic.oup.com
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …
Peripheral itch sensitization in atopic dermatitis
M Tominaga, K Takamori - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …
TRPV1-targeted drugs in development for human pain conditions
The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …
[HTML][HTML] The genetics of chronic itch: gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch
LA Nattkemper, HL Tey, R Valdes-Rodriguez… - Journal of Investigative …, 2018 - Elsevier
To identify itch-related mediators and receptors that are differentially expressed in pruritic
skin, we used RNA sequencing to analyze the complete transcriptome in skin from paired …
skin, we used RNA sequencing to analyze the complete transcriptome in skin from paired …
Involvement of neural transient receptor potential channels in peripheral inflammation
HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
Mediators of chronic pruritus in atopic dermatitis: getting the itch out?
NK Mollanazar, PK Smith, G Yosipovitch - Clinical reviews in allergy & …, 2016 - Springer
For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …