Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Caenorhabditis elegans is an important model organism with many useful features,
including rapid development and aging, easy cultivation, and genetic tractability. Survival …

Numerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in
maintaining health, especially during ageing. Even neurodegeneration, which is part of the …

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple
species including worms, flies and mice. Here, we study three C. elegans mitochondrial …

Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively
utilized as an animal model for research involving aging and neurodegenerative diseases …

Since the discovery of single gene mutations that double its lifespan, the nematode
Caenorhabditis elegans has provided remarkable insights into the biology of aging. The …

Retrograded starch is known to be resistant to digestion. We used enzyme kinetic
experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine …

Background The mitochondrial unfolded protein response (mitoUPR) is a stress response
pathway activated by disruption of proteostasis in the mitochondria. This pathway has been …

Limiting the debilitating consequences of ageing is a major medical challenge of our time.
Robust pharmacological interventions that promote healthy ageing across diverse genetic …

We review the findings that establish that perturbations of various aspects of mitochondrial
function, including oxidative phosphorylation, can promote lifespan extension, with different …