Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

In their seminal 1983 paper, Gans and Northcutt proposed that evolution of the vertebrate
'new head'was made possible by the advent of the neural crest and cranial placodes. The …

Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought
to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it …

Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of
life. The peripheral nervous system has an inherent capability to regenerate axons …

Neural crest (NC) cells arise early in vertebrate development, migrate extensively and
contribute to a diverse array of ectodermal and mesenchymal derivatives. Previous models …

Debate remains around the anatomical origins of specific brain cell subtypes and lineage
relationships within the human forebrain,,,,,–. Thus, direct observation in the mature human …

The developmental origin of vascular smooth muscle cells (VSMCs) has been increasingly
recognized as a major determinant for regional susceptibility or resistance to vascular …

Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor
deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self …