Susceptibility and resilience to stress depend on 1) the timing of the exposure with respect to
development, 2) the time across the life span at which effects are measured, and 3) the …

A growing body of research has examined the impact of childhood adversity on neural
structure and function. Advances in our understanding of the neurodevelopmental …

Despite long-standing interest in the influence of adverse early experiences on mental
health, systematic scientific inquiry into childhood adversity and developmental outcomes …

Children exposed to various forms of adversity early in life are at increased risk for a broad
range of developmental difficulties, affecting both cognitive and emotional adjustment. We …

An obvious consequence of the coronavirus disease (COVID-19) pandemic is the worldwide
reduction in social interaction, which is associated with many adverse effects on health in …

Emerging evidence suggests that partially distinct mechanisms may underlie the association
between different dimensions of early life adversity (ELA) and psychopathology in children …

The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …

Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala
are immature during childhood and become adult-like during adolescence. Rodent models …

Physical, sexual, and emotional abuse and various forms of neglect of children are
associated with substantially increased risk for concurrent and subsequent psychopathology …

Hypotheses concerning the biologic embedding of early adversity via developmental
neuroplasticity mechanisms have been proposed on the basis of experimental studies in …