Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a
broad range of excitable and non-excitable cell types and are found in organisms ranging …

Kv7 channels are enriched at the axonal plasma membrane where their voltage-dependent
potassium currents suppress neuronal excitability. Mutations in Kv7. 2 and Kv7. 3 subunits …

Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and
controlled by a complement of ion channels it expresses, in order to understand and treat …

Zinc (Zn) is an essential trace element; it serves as a cofactor for a great number of enzymes,
transcription factors, receptors, and other proteins. Zinc is also an important signaling …

Neuronal excitation imposes a high demand of ATP in neurons. Most of the ATP derives
primarily from pyruvate-mediated oxidative phosphorylation, a process that relies on import …

Voltage-gated potassium 7.1 (Kv7. 1) channel and KCNE1 protein coassembly forms the
slow potassium current IKS that repolarizes the cardiac action potential. The physiological …

Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …

Phosphatidylinositol 4, 5-bisphosphate (PIP 2) in the plasma membrane regulates the
function of many ion channels, including M-type (potassium voltage-gated channel …

K v 7 (“M-type,” KCNQ) K+ currents, play dominant roles in controlling neuronal excitability.
They act as a “brake” against hyperexcitable states in the central and peripheral nervous …