Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
Macrocyclization and backbone modification in RiPP biosynthesis
H Lee, WA Van Der Donk - Annual review of biochemistry, 2022 - annualreviews.org
The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …
Exploring the diverse landscape of biaryl-containing peptides generated by cytochrome P450 macrocyclases
Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …
Bioinformatic atlas of radical SAM enzyme-modified RiPP natural products reveals an isoleucine–tryptophan crosslink
KA Clark, MR Seyedsayamdost - Journal of the American …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …
family of natural products with diverse activities and structures. RiPP classes are defined by …
The biosynthetic landscape of triceptides reveals radical SAM enzymes that catalyze cyclophane formation on Tyr-and His-containing motifs
Peptide-derived cyclophanes inhabit a unique niche in the chemical space of macrocyclic
peptides with several examples of pharmaceutical importance. Although both synthetic and …
peptides with several examples of pharmaceutical importance. Although both synthetic and …
Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-butyrine crosslinks
Y Li, Y Ma, Y Xia, T Zhang, S Sun, J Gao, H Yao… - Nature …, 2023 - nature.com
Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …
Dehydroamino acid residues in bioactive natural products
S Wang, K Wu, YJ Tang, H Deng - Natural Product Reports, 2024 - pubs.rsc.org
Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …
N–Cα bond cleavage catalyzed by a multinuclear iron oxygenase from a divergent methanobactin-like RiPP gene cluster
VT Chioti, KA Clark, JG Ganley, EJ Han… - Journal of the …, 2024 - ACS Publications
DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes
involved in the biosynthesis of ribosomally synthesized and post-translationally modified …
involved in the biosynthesis of ribosomally synthesized and post-translationally modified …
An intramolecular macrocyclase in plant ribosomal peptide biosynthesis
LS Mydy, J Hungerford, DN Chigumba… - Nature chemical …, 2024 - nature.com
The biosynthetic dogma of ribosomally synthesized and posttranslationally modified
peptides (RiPP) involves enzymatic intermolecular modification of core peptide motifs in …
peptides (RiPP) involves enzymatic intermolecular modification of core peptide motifs in …
Gene-guided discovery and ribosomal biosynthesis of moroidin peptides
Moroidin is a bicyclic plant octapeptide with tryptophan side-chain cross-links, originally
isolated as a pain-causing agent from the Australian stinging tree Dendrocnide moroides …
isolated as a pain-causing agent from the Australian stinging tree Dendrocnide moroides …