Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

The past decade has seen impressive advances in understanding the biosynthesis of
ribosomally synthesized and posttranslationally modified peptides (RiPPs). One of the most …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …

Peptide-derived cyclophanes inhabit a unique niche in the chemical space of macrocyclic
peptides with several examples of pharmaceutical importance. Although both synthetic and …

Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …

Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …

DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes
involved in the biosynthesis of ribosomally synthesized and post-translationally modified …

The biosynthetic dogma of ribosomally synthesized and posttranslationally modified
peptides (RiPP) involves enzymatic intermolecular modification of core peptide motifs in …

Moroidin is a bicyclic plant octapeptide with tryptophan side-chain cross-links, originally
isolated as a pain-causing agent from the Australian stinging tree Dendrocnide moroides …