Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

LncRNA PVT1 promotes angiogenesis via activating the STAT3/VEGFA axis in gastric cancer

J Zhao, P Du, P Cui, Y Qin, C Hu, J Wu, Z Zhou… - Oncogene, 2018 - nature.com
Angiogenesis can aggravate gastric cancer progression. LncRNAs exert important roles in
regulating various cancer behaviors. However, the functions and mechanisms of lncRNAs in …

Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer

J Chen, Y Yu, H Li, Q Hu, X Chen, Y He, C Xue, F Ren… - Molecular cancer, 2019 - Springer
Background The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an
oncogenic regulator of several cancers. However, its expression and function in gallbladder …

Long noncoding RNA and cancer: a new paradigm

A Bhan, M Soleimani, SS Mandal - Cancer research, 2017 - AACR
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1α

Y Wang, W Chen, J Lian, H Zhang, B Yu… - Cell Death & …, 2020 - nature.com
Long noncoding RNAs (lncRNAs) play important roles in regulating the development and
progression of many cancers. However, the clinical significance of specific lncRNAs in the …

[HTML][HTML] Molecular mechanisms of long noncoding RNAs on gastric cancer

T Li, X Mo, L Fu, B Xiao, J Guo - Oncotarget, 2016 - ncbi.nlm.nih.gov
Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200
nucleotides. Aberrant expression of lncRNAs has been found associated with gastric cancer …

A Positive Feedback Loop of lncRNA-PVT1 and FOXM1 Facilitates Gastric Cancer Growth and Invasion

M Xu, Y Wang, W Weng, P Wei, P Qi, Q Zhang… - Clinical Cancer …, 2017 - AACR
Purpose: The long, noncoding RNA (lncRNA) PVT1 is an important epigenetic regulator with
a critical role in human tumors. Here, we aimed to investigate the clinical application and the …

[HTML][HTML] The role of miRNA and lncRNA in gastric cancer

NB Hao, YF He, XQ Li, K Wang, RL Wang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Gastric cancer is one of the most common cancers and has the highest mortality rate
worldwide. It is worthwhile to explore the mechanism of gastric cancer progression. An …