Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

H Sadrekarimi, ZR Gardanova, M Bakhshesh… - Journal of translational …, 2022 - Springer
In recent years, there has been a greater emphasis on the impact of microbial populations
inhabiting the gastrointestinal tract on human health and disease. According to the …

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

LE Wroblewski, RM Peek Jr… - Clinical microbiology …, 2010 - Am Soc Microbiol
Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's
population. Infection with H. pylori causes chronic inflammation and significantly increases …

Pathogenesis of Helicobacter pylori Infection

JG Kusters, AHM Van Vliet… - Clinical microbiology …, 2006 - Am Soc Microbiol
Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the
most successful human pathogens, as over half of the world's population is colonized with …

Mechanisms of disease: Helicobacter pylori virulence factors

Y Yamaoka - Nature reviews Gastroenterology & hepatology, 2010 - nature.com
Helicobacter pylori plays an essential role in the development of various gastroduodenal
diseases; however, only a small proportion of people infected with H. pylori develop these …

Helicobacter pylori in health and disease

TL Cover, MJ Blaser - Gastroenterology, 2009 - Elsevier
Helicobacter pylori is highly adapted for colonization of the human stomach and is present in
about half of the human population. When present, H pylori is usually the numerically …

THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES

JC Atherton - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Helicobacter pylori is the main cause of peptic ulceration, distal gastric adenocarcinoma,
and gastric lymphoma. Only 15% of those colonized develop disease, and pathogenesis …

Persistent bacterial infections: the interface of the pathogen and the host immune system

DM Monack, A Mueller, S Falkow - Nature Reviews Microbiology, 2004 - nature.com
Persistent bacterial infections involving Mycobacterium tuberculosis, Salmonella enterica
serovar Typhi (S. typhi) and Helicobacter pylori pose significant public-health problems …

Helicobacter infection and gastric neoplasia

RM Peek Jr, JE Crabtree - The Journal of Pathology: A Journal …, 2006 - Wiley Online Library
Chronic gastritis induced by Helicobacter pylori is the strongest known risk factor for
adenocarcinoma of the distal stomach, yet only a minority of people who harbour this …

Helicobacter pylori VacA, a paradigm for toxin multifunctionality

TL Cover, SR Blanke - Nature Reviews Microbiology, 2005 - nature.com
Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to
successfully colonize their hosts. In recent years, there has been increased recognition that …

An Overview of Helicobacter pylori VacA Toxin Biology

NJ Foegeding, RR Caston, MS McClain, MD Ohi… - Toxins, 2016 - mdpi.com
The VacA toxin secreted by Helicobacter pylori enhances the ability of the bacteria to
colonize the stomach and contributes to the pathogenesis of gastric adenocarcinoma and …