Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …

Most life scientists would agree that understanding how cellular processes work requires
structural knowledge about the macromolecules involved. For example, deciphering the …

Microtubules play crucial roles in cellular architecture, intracellular transport, and mitosis.
The availability of free tubulin subunits affects polymerization dynamics and microtubule …

The endosomal system orchestrates the transport of lipids, proteins and nutrients across the
entire cell. Along their journey, endosomes mature, change shape via fusion and fission …

The cell orchestrates the dance of chromosome segregation with remarkable speed and
fidelity. The mitotic spindle is built from scratch after interphase through microtubule (MT) …

Abl family kinases are evolutionarily conserved regulators of cell migration and
morphogenesis. Genetic experiments in Drosophila suggest that Abl family kinases interact …

Subcortical heterotopia is a cortical malformation associated with epilepsy, intellectual
disability, and an excessive number of cortical neurons in the white matter. Echinoderm …

Tubulin post-translational modifications (PTMs) alter microtubule properties by affecting the
binding of microtubule-associated proteins (MAPs). Microtubule detyrosination, which …

The microtubule-associated protein MAP1B has been implicated in axonal growth and brain
development. We found that MAP1B is highly expressed in the most aggressive and …

Cells generate a highly diverse microtubule network to carry out different activities. This
network is comprised of distinct tubulin isotypes, tubulins with different post-translational …