The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Mitochondrial-derived peptides (MDPs) are small bioactive peptides encoded by short open-
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …

Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

Exercise, in the form of endurance or resistance training, leads to specific molecular and
cellular adaptions not only in skeletal muscles, but also in many other organs such as the …

Abstract Background Mitochondria-derived peptides (MDPs) represent a recently discovered
family of peptides encoded by short open reading frames (ORFs) found within mitochondrial …

Vascular mitochondria constantly integrate signals from environment and respond
accordingly to match vascular function to metabolic requirements of the organ tissues, while …

Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

Physical activity is associated with beneficial adaptations in human and rodent metabolism.
We studied over 50 complex traits before and after exercise intervention in middle-aged men …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …