Variations in Intracellular Organometallic Reaction Frequency Captured by Single‐Molecule Fluorescence Microscopy

D Nguyen, G Yan, TY Chen, LH Do - Angewandte Chemie, 2023 - Wiley Online Library
Studies of organometallic reactions in living cells commonly rely on ensemble‐averaged
measurements, which can obscure the detection of reaction dynamics or location‐specific …

Advancements and Practical Considerations for Biophysical Research: Navigating the Challenges and Future of Super-resolution Microscopy

H Chen, G Yan, MH Wen, KN Brooks… - … & Biomedical Imaging, 2024 - ACS Publications
The introduction of super-resolution microscopy (SRM) has significantly advanced our
understanding of cellular and molecular dynamics, offering a detailed view previously …

From Monomers to Hexamers: A Theoretical Probability of the Neighbor Density Approach to Dissect Protein Oligomerization in Cells

H Chen, TY Chen - Analytical Chemistry, 2023 - ACS Publications
Deciphering the oligomeric state of proteins within cells is pivotal to understanding their role
in intricate cellular processes. With the recent advances in single-molecule localization …

Probing oxidant effects on superoxide dismutase 1 oligomeric states in live cells using single-molecule fluorescence anisotropy

H Chen, TY Chen - Chemical & Biomedical Imaging, 2023 - ACS Publications
The protein Cu/Zn superoxide dismutase (SOD1) is known to function as a dimer, but its
concentration in cells (∼ 50 μM) and the dimerization constant (K d of 500 μM) results …

From Molecules to Classrooms: A Comprehensive Guide to Single-Molecule Localization Microscopy

G Yan, Y Zhang, A Allamprese, KN Brooks… - Journal of Chemical …, 2024 - ACS Publications
Single-molecule localization microscopy (SMLM) has revolutionized our ability to visualize
cellular structures, offering unprecedented detail. However, the intricate biophysical …

Disperse Red 1 azo dye: consequences of low-dose/low-concentration exposures in mice and zebrafish

FH Fernandes, FR Abe, TB Gomes… - … -Genetic Toxicology and …, 2024 - Elsevier
Abstract Color Index Disperse Red 1 (DR1), an azo dye widely used in the textile industry
and released into aquatic environments, is genotoxic in somatic cells, but little is known …