Vaccines for human fungal diseases: close but still a long way to go
Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …
[HTML][HTML] Immunity to Cryptococcus neoformans and C. gattii during cryptococcosis
JF Gibson, SA Johnston - Fungal Genetics and Biology, 2015 - Elsevier
The vast majority of infection with cryptococcal species occurs with Cryptococcus
neoformans in the severely immunocompromised. A significant exception to this is the …
neoformans in the severely immunocompromised. A significant exception to this is the …
Paradoxical immune responses in non-HIV cryptococcal meningitis
AA Panackal, SC Wuest, YC Lin, T Wu, N Zhang… - PLoS …, 2015 - journals.plos.org
The fungus Cryptococcus is a major cause of meningoencephalitis in HIV-infected as well as
HIV-uninfected individuals with mortalities in developed countries of 20% and 30 …
HIV-uninfected individuals with mortalities in developed countries of 20% and 30 …
Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection
C Firacative, AE Gressler, K Schubert, B Schulze… - Scientific reports, 2018 - nature.com
Cryptococcosis, caused by Cryptococcus neoformans, has been demonstrated to be
controlled by T helper (Th) 1 cells while Th2 cells are associated with fungal growth and …
controlled by T helper (Th) 1 cells while Th2 cells are associated with fungal growth and …
Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome
Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening
disease. These fungi commonly enter their host via inhalation into the lungs where they …
disease. These fungi commonly enter their host via inhalation into the lungs where they …
Antifungal resistance, metabolic routes as drug targets, and new antifungal agents: an overview about endemic dimorphic fungi
JA Parente-Rocha, AM Bailão… - Mediators of …, 2017 - Wiley Online Library
Diseases caused by fungi can occur in healthy people, but immunocompromised patients
are the major risk group for invasive fungal infections. Cases of fungal resistance and the …
are the major risk group for invasive fungal infections. Cases of fungal resistance and the …
Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model
AC Colombo, A Rella, T Normile, LS Joffe, PM Tavares… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is an encapsulated fungal pathogen that causes
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …
Immunology of cryptococcal infections: developing a rational approach to patient therapy
W Elsegeiny, KA Marr, PR Williamson - Frontiers in immunology, 2018 - frontiersin.org
Cryptococcal meningoencephalitis is responsible for upwards of 15% of HIV-related deaths
worldwide and is currently the most common cause of non-viral meningitis in the US …
worldwide and is currently the most common cause of non-viral meningitis in the US …
Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection
Y Wang, S Pawar, O Dutta, K Wang… - Frontiers in Cellular …, 2022 - frontiersin.org
Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …
defense against pathogens to modulate homeostatic and inflammatory responses. They …
Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
F Almeida, JM Wolf, TA Da Silva… - Nature …, 2017 - nature.com
Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis,
which is a major opportunistic infection in immunosuppressed individuals. Mammalian β …
which is a major opportunistic infection in immunosuppressed individuals. Mammalian β …