Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Flipper probes have been introduced as small molecule fluorophores to image physical
forces, that is, membrane tension in living systems. Their emergence over one decade is …

Lipid mobilization through fatty acid β-oxidation is a central process essential for energy
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …

Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue
(WAT), has reached pandemic proportions and acts as a primer for a wide range of …

In the last decade, molecular dynamics (MD) simulations have become an essential tool to
investigate the molecular properties of membrane trafficking processes, often in conjunction …

Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress
conditions, allowing them to persist and ultimately develop resistance. We report that a …

Measuring forces within living cells remains a technical challenge. In this Tutorial, we cover
the development of hydrophobic mechanosensing fluorescent probes called Flippers …

Impaired proinsulin-to-insulin processing in pancreatic β-cells is a key defective step in both
type 1 diabetes and type 2 diabetes (T2D)(refs.,), but the mechanisms involved remain to be …

Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization
and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein …

Background Lipids play a vital role in health and disease, but changes to their circulating
levels and the link with obesity remain poorly characterized in expecting mothers and their …