Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades,
yet the molecular mechanisms at the core of this damage remain largely unknown …

Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates. A
high level of unconjugated bilirubin that is unbound to albumin is neurotoxic when the level …

Hepatic encephalopathy (HE) is a deterioration of brain function in patients suffering from
chronic liver disease, cirrhosis as a result of elevated blood ammonia and the production of …

Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how
bilirubin worsens outcomes remains mysterious. We report that post-, but not pre-, stroke …

The giant panda Ailuropoda melanoleuca belongs to the family of Ursidae; however, it is not
carnivorous, feeding almost exclusively on bamboo. Being equipped with a typical …

Significance: The p53 family of transcription factors, including p53, p63, and p73, plays key
roles in both biological and pathological processes, including cancer and neural …

Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.
However, at high concentrations, it produces severe neurological damage and death …

Hyperbilirubinemia is the most common reason for consultation and hospitalization in the
neonatal period. It requires a timely initiation of an effective treatment because newborn …

Objective Jaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the
tissue and is indicative of potential toxicity to the brain. Since its very first description more …

Bilirubin neurotoxicity is a serious consequence of hyperbilirubinemia, which is the most
common disease of the neonatal period. Clinically, bilirubin neurotoxicity can result in motor …