[HTML][HTML] Prominent receptors of liver sinusoidal endothelial cells in liver homeostasis and disease
E Pandey, AS Nour, EN Harris - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …
[HTML][HTML] Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A
Factor VIII gene transfer with a single intravenous infusion of valoctocogene roxaparvovec
(AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years to date in people with …
(AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years to date in people with …
[HTML][HTML] Tolerating factor VIII: recent progress
S Lacroix-Desmazes, J Voorberg, D Lillicrap… - Frontiers in …, 2020 - frontiersin.org
Development of neutralizing antibodies against biotherapeutic agents administered to
prevent or treat various clinical conditions is a longstanding and growing problem faced by …
prevent or treat various clinical conditions is a longstanding and growing problem faced by …
[HTML][HTML] L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), remains a pandemic. Severe disease is associated …
syndrome coronavirus 2 (SARS-CoV-2), remains a pandemic. Severe disease is associated …
Biological mechanisms underlying inter‐individual variation in factor VIII clearance in haemophilia
PL Turecek, JM Johnsen, SW Pipe, JS O'Donnell… - …, 2020 - Wiley Online Library
Previous studies have highlighted marked inter‐individual variations in factor VIII (FVIII)
clearance between patients with haemophilia (PWH). The half‐life of infused FVIII has been …
clearance between patients with haemophilia (PWH). The half‐life of infused FVIII has been …
[HTML][HTML] Plasma clearance of coagulation factor VIII and extension of its half-life for the therapy of hemophilia A: A critical review of the current state of research and …
AG Sarafanov - International Journal of Molecular Sciences, 2023 - mdpi.com
Factor VIII (FVIII) is an important component of blood coagulation as its congenital deficiency
results in life-threatening bleeding. Current prophylactic therapy of the disease (hemophilia …
results in life-threatening bleeding. Current prophylactic therapy of the disease (hemophilia …
Conductance artery wall layers and their respective roles in the clearance functions
JB Michel, J Lagrange, V Regnault… - … , and vascular biology, 2022 - Am Heart Assoc
Evolutionary organization of the arterial wall into layers occurred concomitantly with the
emergence of a highly muscularized, pressurized arterial system that facilitates outward …
emergence of a highly muscularized, pressurized arterial system that facilitates outward …
Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients
LL Swystun, K Ogiwara, O Rawley… - Blood, The Journal …, 2019 - ashpublications.org
Abstract Factor VIII (FVIII) pharmacokinetic (PK) properties show high interpatient variability
in hemophilia A patients. Although previous studies have determined that age, body mass …
in hemophilia A patients. Although previous studies have determined that age, body mass …
Advances in knowledge of inhibitor formation in severe haemophilia A
M Cormier, P Batty, J Tarrant… - British Journal of …, 2020 - Wiley Online Library
Anti‐drug antibody formation following factor VIII (FVIII) replacement therapy is the most
important treatment‐related complication in patients with severe haemophilia A. A significant …
important treatment‐related complication in patients with severe haemophilia A. A significant …
Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders
W Alam - SAGE open medicine, 2021 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus-2 has emerged as a new viral pandemic,
causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging …
causing Coronavirus disease 2019 (COVID-19) leading to a wide array of symptoms ranging …