Cellular pathways influenced by protein arginine methylation: Implications for cancer
Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
RNA binding proteins, and many other cellular proteins, affecting their function by altering …
Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
W Li, Y He, J Yang, G Hu, Y Lin, T Ran, B Peng… - Nature …, 2021 - nature.com
Numerous substrates have been identified for Type I and II arginine methyltransferases
(PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its …
(PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its …
[HTML][HTML] The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
N Stopa, JE Krebs, D Shechter - Cellular and molecular life sciences, 2015 - Springer
Post-translational arginine methylation is responsible for regulation of many biological
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
J Fuhrmann, KW Clancy, PR Thompson - Chemical reviews, 2015 - ACS Publications
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
Protein arginine methyltransferase 5 (PRMT5) inhibitors in oncology clinical trials: a review
K Feustel, GS Falchook - Journal of Immunotherapy and …, 2022 - meridian.allenpress.com
ABSTRACT Protein arginine methyltransferase 5 (PRMT5) inhibitors are a new class of
antineoplastic agents showing promising preliminary clinical efficacy. Targeting an enzyme …
antineoplastic agents showing promising preliminary clinical efficacy. Targeting an enzyme …
PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1–
9), whose members can catalyse three distinct types of methylation on arginine residues …
9), whose members can catalyse three distinct types of methylation on arginine residues …
Proteomics profiling of arginine methylation defines PRMT5 substrate specificity
D Musiani, J Bok, E Massignani, L Wu, T Tabaglio… - Science …, 2019 - science.org
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both
chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the …
chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the …
The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
X Bai, C Sui, F Liu, T Chen, L Zhang, Y Zheng… - Nature …, 2022 - nature.com
The signaling adaptor MAVS forms prion-like aggregates to activate the innate antiviral
immune response after viral infection. However, spontaneous aggregation of MAVS can …
immune response after viral infection. However, spontaneous aggregation of MAVS can …
[HTML][HTML] Cellular consequences of arginine methylation
BM Lorton, D Shechter - Cellular and Molecular Life Sciences, 2019 - Springer
Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …