Single nucleotide polymorphisms (SNPs) are the most frequent type of genetic alterations
between individuals. An SNP located within the coding sequence of a gene may lead to an …

A great deal of interest has recently focused on conducting inference on the parameters in a
high-dimensional linear model. In this paper, we consider a simple and very naïve two-step …

Typical features of dyskeratosis congenita (DC) resulting from excessive telomere
shortening include bone marrow failure (BMF), mucosal fragility, and pulmonary or liver …

Background Neuroblastoma, a neuroendocrine tumor originating from the sympathetic
ganglia, is one of the most common malignancies in childhood. RTEL1 is critical in many …

Long noncoding RNA (lncRNA) polymorphisms are reportedly in connection with tumor
susceptibility and prognosis. Glioma is one of the most aggressive and common cancers of …

Background Glioma, the most common primary malignant brain tumor, is highly malignant
with a poor prognosis. We aimed to clarify the relevance of ANXA5 polymorphisms to glioma …

MicroRNAs bind to the 3′ untranslated regions of mRNAs, affecting translation,
tumorigenesis, and apoptosis. This study evaluated the role of TYMS (rs1059394, C> T, and …

Circular RNAs (circRNAs), forming a covalently closed loop, are identified as a special
subgroup of non-coding RNAs. Herein, we investigated the function and underlying …

Purpose Glioma is the most common primary malignant brain tumor with high mortality and
poor prognosis. Our aim was to clarify the correlation between Kinase-anchored protein 6 …

Adaptation of humans to challenging environmental conditions, such as extreme
temperature, malnutrition, or hypoxia, is an interesting phenomenon for both basic and …