Hamsters as a model of severe acute respiratory syndrome coronavirus-2

AM Braxton, PS Creisher, CA Ruiz-Bedoya… - Comparative …, 2021 - ingentaconnect.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus
disease 2019 (COVID-19), rapidly spread across the world in late 2019, leading to a …

AZD1222-induced nasal antibody responses are shaped by prior SARS-CoV-2 infection and correlate with virologic outcomes in breakthrough infection

AA Aksyuk, H Bansal, D Wilkins, AM Stanley… - Cell Reports …, 2023 - cell.com
The nasal mucosa is an important initial site of host defense against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection. However, intramuscularly administered …

A bacteriophage-based, highly efficacious, needle-and adjuvant-free, mucosal COVID-19 vaccine

J Zhu, S Jain, J Sha, H Batra, N Ananthaswamy… - MBio, 2022 - Am Soc Microbiol
ABSTRACT The US Food and Drug Administration-authorized mRNA-and adenovirus-
based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in …

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa

B Vesin, J Lopez, A Noirat, P Authié, I Fert… - Molecular Therapy, 2022 - cell.com
As the coronavirus disease 2019 (COVID-19) pandemic continues and new severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern emerge, the adaptive …

Inhalation of vaccines and antiviral drugs to fight respiratory virus infections: reasons to prioritize the pulmonary route of administration

R Heida, HW Frijlink, WLJ Hinrichs - Mbio, 2023 - Am Soc Microbiol
Many of the current pandemic threats are caused by viruses that infect the respiratory tract.
Remarkably though, the majority of vaccines and antiviral drugs are administered via …

A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice

JB Case, S Sanapala, C Dillen, V Rhodes, C Zmasek… - Cell Host & Microbe, 2024 - cell.com
The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus
zoonoses have spurred the design of vaccines that can induce broad immunity against …

The highly conserved stem-loop II motif is dispensable for SARS-CoV-2

H Jiang, A Joshi, T Gan, AB Janowski, C Fujii… - Journal of …, 2023 - Am Soc Microbiol
The stem-loop II motif (s2m) is an RNA structural element that is found in the 3′
untranslated region (UTR) of many RNA viruses, including severe acute respiratory …

mRNA-1273 and Ad26. COV2. S vaccines protect against the B. 1.621 variant of SARS-CoV-2

TL Darling, B Ying, B Whitener, LA VanBlargan… - Med, 2022 - cell.com
Background Since the emergence of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in 2019, viral variants with greater transmissibility or immune-evasion …

Prototype and BA. 5 protein nanoparticle vaccines protect against Omicron BA. 5 variant in Syrian hamsters

TL Bricker, A Joshi, N Soudani, SM Scheaffer… - Journal of …, 2024 - Am Soc Microbiol
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
with greater transmissibility or immune evasion properties has jeopardized the existing …

Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals

ND Aljehani, L Tamming, MY Khan, RH Abdulal… - mBio, 2024 - journals.asm.org
The COVID-19 pandemic has emphasized the importance and need for accessible safe,
effective, and versatile vaccine platforms. While approved SARS-CoV-2 vaccines have been …