Stereoselective synthesis of γ-amino acids
M Ordonez, C Cativiela - Tetrahedron: Asymmetry, 2007 - Elsevier
γ-Amino acids have attracted considerable attention as biologically active compounds in the
central nervous system (CNS) of mammals. Over the last few years, significant interest in the …
central nervous system (CNS) of mammals. Over the last few years, significant interest in the …
GABA‐ρ receptors: distinctive functions and molecular pharmacology
The homomeric GABA‐ρ ligand‐gated ion channels (also known as GABAC or GABAA‐ρ
receptors) are similar to heteromeric GABAA receptors in structure, function and mechanism …
receptors) are similar to heteromeric GABAA receptors in structure, function and mechanism …
The enantiomers of syn-2, 3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA C receptor
I Yamamoto, MJT Jordan, N Gavande… - Chemical …, 2012 - pubs.rsc.org
The conformational behaviour and GABA receptor activity of the different stereoisomers of 2,
3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABAC-active ligands are …
3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABAC-active ligands are …
Neurochemicals for the Investigation of GABAC Receptors
GAR Johnston, M Chebib, JR Hanrahan… - Neurochemical …, 2010 - Springer
GABA C receptors are being investigated for their role in many aspects of nervous system
function including memory, myopia, pain and sleep. There is evidence for functional GABA C …
function including memory, myopia, pain and sleep. There is evidence for functional GABA C …
Multi-functional diarylurea small molecule inhibitors of TRPV1 with therapeutic potential for neuroinflammation
Transient receptor potential vanilloid type 1 (TRPV1), a heat-sensitive calcium channel
protein, contributes to inflammation as well as to acute and persistent pain. Since TRPV1 …
protein, contributes to inflammation as well as to acute and persistent pain. Since TRPV1 …
Medicinal Chemistry of ρ GABAC Receptors
CKL Ng, H Kim, N Gavande, I Yamamoto… - Future medicinal …, 2011 - Taylor & Francis
The inhibitory neurotransmitter, GABA, is a low-molecular-weight molecule that can achieve
many low-energy conformations, which are recognized by GABA receptors and transporters …
many low-energy conformations, which are recognized by GABA receptors and transporters …
A Molecular Basis for Agonist and Antagonist Actions at GABAC Receptors
H Abdel‐Halim, JR Hanrahan, DE Hibbs… - Chemical biology & …, 2008 - Wiley Online Library
We modelled the N‐terminal ligand‐binding domain of the ρ1 GABAC receptor based on the
Lymnaea stagnalis acetylcholine‐binding protein (L‐AChBP) crystal structure using …
Lymnaea stagnalis acetylcholine‐binding protein (L‐AChBP) crystal structure using …
Scope, limitations and classification of lactamases
Z Assaf, K Faber, M Hall - Journal of Biotechnology, 2016 - Elsevier
The hydrolysis of amide bonds is a ubiquitous process in nature and is catalyzed by various
enzymes: Whereas N-unsubstituted amides are cleaved by amidases (EC 3.5. 1.4) …
enzymes: Whereas N-unsubstituted amides are cleaved by amidases (EC 3.5. 1.4) …
Agonist responses of (R)-and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA C receptors
I Yamamoto, GP Deniau, N Gavande… - Chemical …, 2011 - pubs.rsc.org
The enantiomers of 3F-GABA were evaluated on GABAC receptors. Both enantiomers were
agonists, with the (R)-enantiomer being an order of magnitude more potent. This result is …
agonists, with the (R)-enantiomer being an order of magnitude more potent. This result is …
A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold
KP Melnykov, DM Volochnyuk, SV Ryabukhin… - Amino Acids, 2019 - Springer
An approach to rel-(4a S, 6 R, 7a R)-octahydro-1 H-cyclopenta [b] pyridine-6-carboxylic acid—
a bicyclic conformationally restricted γ-aminobutyric acid (GABA) analogue was developed …
a bicyclic conformationally restricted γ-aminobutyric acid (GABA) analogue was developed …