This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

The origins of vascular smooth muscle are far more diverse than previously thought.
Lineage mapping studies show that the segmental organization of early vertebrate embryos …

Mammalian circadian rhythms are regulated by a pacemaker within the suprachiasmatic
nuclei (SCN) of the hypothalamus. The molecular mechanisms controlling the …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

The promoters of many genes whose transcription is rapidly and transiently induced
following growth factor or mitogen stimulation of susceptible cells contain a common …

Growth hormone (GH), a major regulator of normal body growth and metabolism, regulates
cellular gene expression. The transcription factors Elk-1 and Serum Response Factor are …

Synaptic activity-dependent gene expression is critical for certain forms of neuronal plasticity
and survival in the mammalian nervous system, yet the mechanisms by which coordinated …

A signaling pathway by which growth factors may induce transcription of the c-fos proto-
oncogene has been characterized. Growth factor stimulation of quiescent fibroblasts …

Activation of the transcription factor serum response factor (SRF) is dependent on Rho-
controlled changes in actin dynamics. We used pathway-specific inhibitors to compare the …

Enhanced levels of cytoplasmic Ca 2+ due to membrane depolarization with elevated levels
of KCl or exposure to the Ca 2+ ionophore ionomycin stimulate serum response element …